Molecular hybridization is a well-exploited medicinal chemistry strategy that aims to combine
two molecules (or parts of them) in a new, single chemical entity. Recently, it has been …

Tuberculosis (TB) remains a global public health problem in recent years. TB originated
mainly from various strains of Mycobacterium tuberculosis, is a highly infectious and chronic …

About 1.5 million new cases of cutaneous leishmaniasis and 500 000 new cases of visceral
leishmaniasis occur each year around the world. For over half a century, the clinical forms of …

Giardia parasites are ubiquitous protozoans of global importance that impact a wide range
of animals including humans. They are the most common enteric pathogen of cats and dogs …

Giardia intestinalis infection causes enterocytes damage and loss of brush border of the
epithelial cells of the intestine that leads to shortening of microvilli and altered epithelial …

Molecular Hybridization is an approach in rational drug design where new chemical entities
are obtained by combining two or more pharmacophoric units from different bioactive …

The increasing drug resistance of M ycobacterium tuberculosis to the currently used drugs
and HIV coinfection has caused alarm in the international scientific community …

Based on medicinal chemistry tools, new compounds for malaria treatment were designed.
The scaffolds of the drugs used to treat malaria, such as chloroquine, primaquine …

Leishmaniasis is a group of vector-borne, parasitic diseases caused by over 20 species of
the protozoan Leishmania spp. The three major disease classifications, cutaneous, visceral …

Quinoline and its derivatives comprise an important group of heterocyclic compounds that
exhibits a wide range of pharmacological properties such as antibacterial, antiviral …