Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Endothelium‐dependent hyperpolarizing factor (EDHF) is a powerful vasodilator influence in
small resistance arteries and thus an important modulator of blood pressure and flow. As the …

Reactive nitrogen species (RNS) are various nitric oxide–derived compounds, including
nitroxyl anion, nitrosonium cation, higher oxides of nitrogen, S-nitrosothiols, and dinitrosyl …

The large-conductance, calcium-activated potassium channels (BK, also termed BKCa, Slo,
or MaxiK) distributed in both excitable and non-excitable cells are involved in many cellular …

The three subtypes of calcium‐activated potassium channels (KCa) of large, intermediate
and small conductance (BKCa, IKCa and SKCa) are present in the vascular wall. In healthy …

Historically acknowledged as toxic gases, hydrogen sulfide (H2S) and nitric oxide (NO) are
now recognized as the predominant members of a new family of signaling molecules,“ …

Until recently, most of the biological effects of nitric oxide (NO) have been attributed to its
uncharged state (NO), yet NO can also exist in the reduced state as nitroxyl (HNO or NO−) …

Our view of the endothelium was transformed around 30 years ago, from one of an inert
barrier to that of a key endocrine organ central to cardiovascular function. This dramatic …

Large-conductance Ca2+-activated K+ channels facilitate the efflux of K+ ions from a variety
of cells and tissues following channel activation. It is now recognized that BK channels …