[HTML][HTML] Experimental and mathematical approaches for drug delivery for the treatment of wet age-related macular degeneration

EAC Ruiz, KE Swindle-Reilly, ANF Versypt - Journal of Controlled Release, 2023 - Elsevier
Several chronic eye diseases affect the posterior segment of the eye. Among them age-
related macular degeneration can cause vision loss if left untreated and is one of the leading …

Mathematical model of macromolecular drug transport in a partially liquefied vitreous humor

A Khoobyar, AN Penkova… - Journal of Heat …, 2022 - asmedigitalcollection.asme.org
The purpose of this study is to investigate the effect of partial liquefaction (due to ageing) of
the vitreous humor on the transport of ocular drugs. In our model, the gel part of the vitreous …

Measurement of the hydraulic conductivity of the vitreous humor

AN Penkova, S Zhang, MS Humayun… - Journal of porous …, 2020 - dl.begellhouse.com
The hydraulic conductivity of the vitreous humor has been measured for the bovine eye. The
experiment was carried out by placing the vitreous within an upright cylindrical chamber …

[HTML][HTML] Mathematical model for degradation and drug release from an intravitreal biodegradable implant

JA Ferreira, MB Gonçalves, E Gudiño, M Maia… - … & Mathematics with …, 2020 - Elsevier
In this paper we study from a mathematical point of view the drug release and the
degradation process in the context of biodegradable intravitreal implants. In particular, two …

In vivo experimental and analytical studies for bevacizumab diffusion coefficient measurement in the rabbit vitreous humor

S Zhang, A Penkova… - Journal of Heat …, 2021 - asmedigitalcollection.asme.org
In order to measure the effective diffusion coefficient D of Bevacizumab (Avastin, Genentech)
in the vitreous humor, a new technique is developed based on the “contour method” and in …

Analytical and computational modeling of sustained-release drug implants in the vitreous humor

A Khoobyar, A Naghdloo… - Journal of Heat …, 2021 - asmedigitalcollection.asme.org
Sustained ocular drug delivery systems are necessary for patients needing regular drug
therapy since frequent injection is painful, undesirable, and risky. One type of sustained …