Conspectus The widespread presence of hydrocarbons makes C–H functionalization an
attractive alternative to traditional cross-coupling methods. As indole is an important …

Metal‐catalyzed cross‐coupling reactions belong to the most important transformations in
organic synthesis. Copper catalysis has received great attention owing to the low toxicity …

The chemistry of copper is extremely rich because it can easily access Cu0, CuI, CuII, and
CuIII oxidation states allowing it to act through one-electron or two-electron processes. As a …

Intellectual curiosity has always been one of the major driving forces leading to new
advances in chemistry. At the onset of the 20th century, the fact that biaryls could be optically …

Chiral molecules containing asymmetric carbon centers bonded with nitrogen are ubiquitous
in nature and also form important structural fragments in both natural and man-made …

The copper‐mediated C (aryl) N, C (aryl) O, and C (aryl) S bond formation is an
important transformation and has been developed to include a wide range of substrates …

Natural product synthesis is a highly demanding field in constant need of efficient
transformations that allow either straightforward, scalable, and high-yielding preparation of …

Glycopeptide antibiotics have been a key weapon in the fight against bacterial infections for
over half a century, with the progenitors, vancomycin (1) and teicoplanin (2), still used …

Metal-catalyzed coupling reactions of aryl electrophiles with organometallics and with
olefins serve as unusually effective tools for forming new carbon− carbon bonds. By 1998 …

The discovery of the copper-promoted Chan-Lam coupling reaction with boronic acids more
than ten years ago has greatly advanced the carbon-heteroatom cross-coupling chemistry …