In this review, we give an overview of recent literature on the structure and stability of
unimolecular G-rich quadruplex structures that are relevant to drug design and for in vivo …

The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

A dynamic programming algorithm for prediction of RNA secondary structure has been
revised to accommodate folding constraints determined by chemical modification and to …

The genetic code is degenerate, in that 20 amino acids are encoded by 61 triplet codes. In
1966, Francis Crick hypothesized that the cell's limited number of tRNAs decoded the …

We compare the diversity of chromosomal-encoded transfer RNA (tRNA) genes from 11
eukaryotes as identified by tRNAScan-SE of their respective genomes. They include the …

RNA structure formation is hierarchical and, therefore, secondary structure, the sum of
canonical base-pairs, can generally be predicted without knowledge of the three …

The core protein of hepatitis C virus (HCV) has been shown previously to act as a potent
nucleic acid chaperone in vitro, promoting the dimerization of the 3′-untranslated region …

Algorithms for predicting RNA secondary structure require approximations for the free
energies of multibranch loops, also called junctions. The stabilities of 62 RNA duplexes with …

The stability of RNA secondary structure can be predicted using a set of nearest neighbor
parameters. These parameters are widely used by algorithms that predict secondary …

Background MicroRNAs (miRNAs) regulate gene expression by targeting complementary
mRNAs for destruction or translational repression. Aberrant expression of miRNAs has been …