Adjuvant physiochemistry and advanced nanotechnology for vaccine development
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …
[HTML][HTML] The role of cGAS-STING signalling in liver diseases
R Chen, J Du, H Zhu, Q Ling - Jhep Reports, 2021 - Elsevier
The recently identified novel cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS)
activates the downstream adaptor protein stimulator of interferon genes (STING) by …
activates the downstream adaptor protein stimulator of interferon genes (STING) by …
A decade of research on the second messenger c-di-AMP
W Yin, X Cai, H Ma, L Zhu, Y Zhang… - FEMS microbiology …, 2020 - academic.oup.com
ABSTRACT Cyclic dimeric adenosine 3′, 5′-monophosphate (c-di-AMP) is an emerging
second messenger in bacteria and archaea that is synthesized from two molecules of ATP …
second messenger in bacteria and archaea that is synthesized from two molecules of ATP …
The cGAS-STING pathway: novel perspectives in liver diseases
D Xu, Y Tian, Q Xia, B Ke - Frontiers in Immunology, 2021 - frontiersin.org
Liver diseases represent a major global health burden accounting for approximately 2
million deaths per year worldwide. The liver functions as a primary immune organ that is …
million deaths per year worldwide. The liver functions as a primary immune organ that is …
[HTML][HTML] The STING ligand cGAMP potentiates the efficacy of vaccine-induced CD8+ T cells
A Gutjahr, L Papagno, F Nicoli, T Kanuma, N Kuse… - JCI insight, 2019 - ncbi.nlm.nih.gov
Pathogen recognition receptor (PRR) agonists are currently being developed and tested as
adjuvants in various formulations to optimize the immunogenicity and efficacy of vaccines …
adjuvants in various formulations to optimize the immunogenicity and efficacy of vaccines …
Ether lipids from archaeas in nano-drug delivery and vaccination
EL Romero, MJ Morilla - International Journal of Pharmaceutics, 2023 - Elsevier
Archaea are microorganisms more closely related to eukaryotes than bacteria. Almost 50
years after being defined as a new domain of life on earth, new species continue to be …
years after being defined as a new domain of life on earth, new species continue to be …
Insights into the biotechnology potential of Methanosarcina
Methanogens are anaerobic archaea which conserve energy by producing methane. Found
in nearly every anaerobic environment on earth, methanogens serve important roles in …
in nearly every anaerobic environment on earth, methanogens serve important roles in …
[HTML][HTML] The STING activator c-di-AMP exerts superior adjuvant properties than the formulation poly (I: C)/CpG after subcutaneous vaccination with soluble protein …
J Volckmar, L Knop, S Stegemann-Koniszewski… - Vaccine, 2019 - Elsevier
Vaccination is the most efficient strategy to protect from infectious diseases and the induction
of a protective immune response not only depends on the nature of the antigen, but is also …
of a protective immune response not only depends on the nature of the antigen, but is also …
STING and liver disease
C Chen, RX Yang, HG Xu - Journal of Gastroenterology, 2021 - Springer
STING (stimulator of interferon genes) also known as transmembrane protein 173
(TMEM173) is a cytoplasmic DNA sensor which can be activated by the upstream cyclic …
(TMEM173) is a cytoplasmic DNA sensor which can be activated by the upstream cyclic …
The promise and challenges of cyclic dinucleotides as molecular adjuvants for vaccine development
H Yan, W Chen - Vaccines, 2021 - mdpi.com
Cyclic dinucleotides (CDNs), originally discovered as bacterial second messengers, play
critical roles in bacterial signal transduction, cellular processes, biofilm formation, and …
critical roles in bacterial signal transduction, cellular processes, biofilm formation, and …