Role of turmeric and curcumin in prevention and treatment of chronic diseases: Lessons learned from clinical trials

AB Kunnumakkara, M Hegde, D Parama… - ACS Pharmacology & …, 2023 - ACS Publications
Turmeric (Curcuma longa) has been used for thousands of years for the prevention and
treatment of various chronic diseases. Curcumin is just one of> 200 ingredients in turmeric …

The anti-inflammatory and immunomodulatory activities of natural products to control autoimmune inflammation

KD Moudgil, SH Venkatesha - International journal of molecular sciences, 2022 - mdpi.com
Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation
of the immune system. This dysregulation involves an imbalance between pro-inflammatory …

Discovery of potential natural dihydroorotate dehydrogenase inhibitors and their synergism with brequinar via integrated molecular docking, dynamic simulations and …

A Khairy, HM Hammoda, I Celik, HH Zaatout… - Scientific Reports, 2022 - nature.com
The critical function of dihydroorotate dehydrogenase (DHODH) in pyrimidine synthesis
attracted a great interest throughout beyond decades. Inhibitors of human DHODH …

Zingiber officinale Roscoe: A comprehensive review of clinical properties

A Bitari, I Oualdi, R Touzani, M Elachouri… - Materials Today …, 2023 - Elsevier
Zingiber officinale Roscoe, commonly known as ginger, is widely used as a spice or a folk
medicine. Such a plant has been incuriously focused on by publishing extensive papers and …

[HTML][HTML] Epigenetics-mediated pathological alternations and their potential in antiphospholipid syndrome diagnosis and therapy

Y Tan, Q Liu, Z Li, S Yang, L Cui - Autoimmunity reviews, 2022 - Elsevier
APS (antiphospholipid syndrome) is a systematic autoimmune disease accompanied with
venous or arterial thrombosis and poor pregnant manifestations, partly attributing to the …

Ethanol-free extraction of curcumin and antioxidant activity of components from wet Curcuma longa L. by liquefied dimethyl ether

H Kanda, L Zhu, W Zhu, T Wang - Arabian Journal of Chemistry, 2023 - Elsevier
As a solvent, ethanol can extract a wide range of polar substances, but its consumption is
sometimes avoided for religious and cultural reasons. In this study, liquefied dimethyl ether …

Emerging trends in curcumin embedded electrospun nanofibers for impaired diabetic wound healing

GP Tamilarasi, M Krishnan, G Sabarees, S Gouthaman… - Applied Nano, 2022 - mdpi.com
Chronic wounds impose a significant burden on individuals and healthcare systems all over
the world. Through clinical and preclinical investigations, inflammation and oxidative …

Mechanism of curcumin in the prevention and treatment of oral submucosal fibrosis and progress in clinical application research

R She, P Xu - BDJ open, 2024 - nature.com
Introduction Oral submucosal fibrosis is a potentially life-threatening oral disease that
significantly impacts physiological functions such as speech and swallowing while also …

Immunomodulatory effects of curcumin on macrophage polarization in rheumatoid arthritis

T Deng, J Xu, Q Wang, X Wang, Y Jiao… - Frontiers in …, 2024 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by synovial
inflammation, cartilage destruction, pannus formation and bone erosion. Various immune …

Melatonin and cisplatin co-treatment against cancer: a mechanistic review of their synergistic effects and melatonin's protective actions

M Rafiyan, A Davoodvandi, RJ Reiter… - … -Research and Practice, 2024 - Elsevier
Combination chemotherapy appears to be a preferable option for some cancer patients,
especially when the medications target multiple pathways of oncogenesis; individuals …