Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …

Bull fertility is an important economic trait in sustainable cattle production, as infertile or
subfertile bulls give rise to large economic losses. Current methods to assess bull fertility are …

Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

Human adult spermatogonial stem cells (hSSCs) must balance self-renewal and
differentiation. To understand how this is achieved, we profiled DNA methylation and open …

Mammalian male germ cell development is a stepwise cell-fate transition process; however,
the full-term developmental profile of male germ cells remains undefined. Here, by …

Spermatogenesis is a classic model of cycling cell lineages that depend on a balance
between stem cell self-renewal for continuity and the formation of progenitors as the initial …

Mammalian spermatogenesis is a highly complex multi-step process sustained by a
population of mitotic germ cells with self-renewal potential known as spermatogonial stem …

In mammalian testes, robust stem cell functions ensure the continual production of sperm. In
testicular seminiferous tubules, spermatogenic stem cells (SSC s) are highly motile and are …

A bioenergetic balance between glycolysis and mitochondrial respiration is particularly
important for stem cell fate specification. It however remains to be determined whether …

STUDY QUESTION Is there a distinct sperm histone-retained epigenetic signature in
unexplained male factor infertility patients resulting in compromised blastocyst …