The past five decades have seen an improvement in the mortality and morbidity of sickle cell
disease (SCD) because of prophylaxis against infectious complications, improved and …

We review the most characteristic clinical and histopathologic findings of the cutaneous
manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high
health care costs. Although episodic acute pain is the hallmark of this disorder, there is an …

摘要背景: 局部应用罂粟碱类可以促进大鼠血管的生成与缺血性伤口的愈合.
我们的目的是调查局部芬太尼麻醉是否通过刺激促生长信号, 血管生成, 淋巴管生成以及神经 …

Idiopathic inflammatory myopathies (IIM) are characterized by muscle inflammation and
weakness, myositis-specific autoantibodies (MSAs), and extramuscular organ damage. The …

Sickle cell anemia (SCA) pathophysiology is characterized by the activation of sickle red
blood cells, reticulocytes, leukocytes, platelets, and endothelial cells, and with the …

Painful vaso‐occlusive crises (VOC s) are the hallmark of sickle cell disease (SCD);
however, many patients experience frequent daily pain that does not follow the pattern of …

Increasing evidence suggests that free haem and iron exert vasculo‐toxic and pro‐
inflammatory effects by activating endothelial and immune cells. In the present retrospective …

Vasculopathy is a hallmark of sickle cell disease ultimately resulting in chronic end organ
damage. Leg ulcer is one of its sequelae, occurring in~ 5–10% of adult sickle cell patients …