Association between high-dose methotrexate-induced toxicity and polymorphisms within methotrexate pathway genes in acute lymphoblastic leukemia

M Xu, S Wu, Y Wang, Y Zhao, X Wang, C Wei… - Frontiers in …, 2022 - frontiersin.org
Methotrexate (MTX) is a folic acid antagonist, the mechanism of action is to inhibit DNA
synthesis, repair and cell proliferation by decreasing the activities of several folate …

[PDF][PDF] Frequency of CYP1A1* 2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

AT Alvarado, AM Muñoz, MS Bartra… - …, 2021 - pharmacia.pensoft.net
The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian
mestizo population. Wild type and mutated genotypes (WT/* 2A and* 2A/* 2A) were …

Site-specific sequence exchange between homologous and non-homologous chromosomes

Q Yin, R Li, DW Ow - Frontiers in Plant Science, 2022 - frontiersin.org
Transgene integration typically takes place in an easy-to-transform laboratory variety before
the transformation event is introgressed through backcrosses to elite cultivars. As new traits …

Genetic variations in cytochrome P450 1A1 and 1B1 genes in a cohort of patients from Iraq diagnosed with breast cancer

SQ Ibrahem, HQ Ahmed… - Breast Cancer: Basic and …, 2021 - journals.sagepub.com
Breast cancer is the most prevalent malignant neoplasm in females. Genetic variations in the
xenobiotic metabolising cytochrome enzymes; Family 1 Subfamily A Member 1 (CYP1A1) …

[HTML][HTML] Sequence polymorphism in xenobiotic metabolising genes in iraqi colorectal cancer patients

SQ Ibrahem, ZT Al-Dalawi… - Asian Pacific journal of …, 2021 - ncbi.nlm.nih.gov
Objectives: Colorectal cancer (CRC) is the third most prevalent malignant neoplasm.
Genetic variations in the xenobiotic metabolising cytochrome enzymes. Family 1 Subfamily …

Preliminary study on local Indonesian sheep MC4R gene as a prospective marker for sustainable high production trait

F Adani, D Maharani, A Sari… - IOP Conference Series …, 2023 - iopscience.iop.org
A prospective genetic marker to archive for sustainable growth traits of local Indonesian
sheep is the Melanocortin-4 Receptor (MC4R) gene, which arrange feeding behavior. This …

GENOTYPING OF CATTLE BY ALLELIC VARIANTS A1 AND A2 OF THE BETA-CASEIN GENE: EMPLOYING DIFFERENT METHODOLOGICAL APPROACHES (AS …

RO Kulibaba, MI Sakhatskyi… - Animal Breeding and …, 2023 - abg-journal.com
This article addresses the comparative analysis of the efficiency of cattle genotyping based
on allelic variants A1 and A2 of the beta-casein gene, employing different methodological …

Analysis of Chosen Polymorphisms rs1982073 T/C, rs1800471 C/G TGFβ1 in Pathogenesis of Hashimoto's Diseases

NN Abed, EA Mahdi - … Academic Journal of Biological Sciences. C …, 2023 - journals.ekb.eg
Hashimoto's thyroiditis is an autoimmune disorder that primarily affects the thyroid gland,
leading to chronic inflammation and impaired thyroid function. On the other hand …

[PDF][PDF] Cellular and molecular mechanisms involved in age-related hearing loss with focusing on oxidative stress

SA Ahmed, ADH Al-Râwanduzi - Central Asian Journal of Medical …, 2022 - academia.edu
Cellular and molecular mechanisms involved in age- related hearing loss with focusing on
oxidative stress Page 1 66 Central Asian Journal of Medical and Pharmaceutical Sciences …

Frequency of CYP1A1* 2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population.

A Tito Alvarado, A María Muñoz… - Pharmacia (0428 …, 2021 - search.ebscohost.com
The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian
mestizo population. Wild type and mutated genotypes (WT/* 2A and* 2A/* 2A) were …