Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Pancreatic cancer is one of the most lethal cancers among all malignances, with a median
overall survival of< 1 year and a 5-year survival of~ 5%. The dismal survival rate and …

Metal ions play a key role in aggregation of amyloid β protein by interfering with their proper
folding, altering protein homeostasis and cell viability, and ultimately leading to …

Zinc finger proteins are one of the most abundant families of proteins and present a wide
range of structures and functions. The structural zinc ion provides the correct conformation to …

MYC is a transcription factor, which not only directly modulates multiple aspects of
transcription and co‐transcriptional processing (eg RNA‐Polymerase II initiation, elongation …

Coordination complexes have emerged as prominent modulators of amyloid aggregation via
their interaction with the N-terminal histidine residues of amyloid-β (Aβ). Herein, we report …

Novel imidazoline based Schiff base ligands L 1 and L 2 were synthesized from o-
phenylenediamine/o-aminophenol with creatinine. The ligands were complexed with Co (II) …

In this work we synthesized a chelating Schiff base by a single condensation of
salicylaldehyde with 3, 4-diamino benzoic acid (1). This ligand was used further for …

The thiophene appended Schiff's base ligand, 1-(2-(thiophen-2-yl) ethylimino) methyl)
naphthalene-2-ol (HL) with N, O donor sites has been synthesized by the condensation …

Cobalt (III) Schiff base complexes ([Co (acacen)(L) 2]+, where L= NH3) inhibit histidine-
containing proteins through dissociative exchange of the labile axial ligands (L). This work …