The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

S Datta, M Cano, K Ebrahimi, L Wang… - Progress in retinal and …, 2017 - Elsevier
The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that
interacts with photoreceptors on its apical side and with Bruch's membrane and the …

Inflammation and its role in age-related macular degeneration

A Kauppinen, JJ Paterno, J Blasiak, A Salminen… - Cellular and molecular …, 2016 - Springer
Inflammation is a cellular response to factors that challenge the homeostasis of cells and
tissues. Cell-associated and soluble pattern-recognition receptors, eg Toll-like receptors …

Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation

M Hata, EMMA Andriessen, M Hata, R Diaz-Marin… - Science, 2023 - science.org
Age-related macular degeneration is a prevalent neuroinflammatory condition and a major
cause of blindness driven by genetic and environmental factors such as obesity. In diseases …

Deep transfer learning approaches to predict glaucoma, cataract, choroidal neovascularization, diabetic macular edema, drusen and healthy eyes: an experimental …

Y Kumar, S Gupta - Archives of Computational Methods in Engineering, 2023 - Springer
Artificial intelligence (AI) has lately witnessed an age of tremendous expansion across
several industries, including healthcare. In recent years, substantial advancements in AI …

Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration

N Golestaneh, Y Chu, YY Xiao, GL Stoleru… - Cell death & …, 2018 - nature.com
Age-related macular degeneration (AMD) is a devastating neurodegenerative disease and a
major cause of blindness in the developed world. Owing to its complexity and the lack of an …

Oxidative stress and antioxidants in age-related macular degeneration

N Kushwah, K Bora, M Maurya, MC Pavlovich, J Chen - Antioxidants, 2023 - mdpi.com
Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies

CA Curcio - Investigative ophthalmology & visual science, 2018 - iovs.arvojournals.org
AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …

Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris …

I Bhutto, G Lutty - Molecular aspects of medicine, 2012 - Elsevier
There is a mutualistic symbiotic relationship between the components of the
photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris …

Immunology of age-related macular degeneration

J Ambati, JP Atkinson, BD Gelfand - Nature Reviews Immunology, 2013 - nature.com
Age-related macular degeneration (AMD) is a leading cause of blindness in aged
individuals. Recent advances have highlighted the essential role of immune processes in …

Age-related macular degeneration: genetics and biology coming together

LG Fritsche, RN Fariss, D Stambolian… - Annual review of …, 2014 - annualreviews.org
Genetic and genomic studies have enhanced our understanding of complex
neurodegenerative diseases that exert a devastating impact on individuals and society. One …