Genetic variation and sickle cell disease severity: a systematic review and meta-analysis

JK Kirkham, JH Estepp, MJ Weiss… - JAMA network …, 2023 - jamanetwork.com
Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Systematic Review of Genetic Modifiers Associated with the Development and/or Progression of Nephropathy in Patients with Sickle Cell Disease

V Labarque, EC Okocha - International Journal of Molecular Sciences, 2024 - mdpi.com
Sickle cell nephropathy (SCN) is a common complication of sickle cell disease (SCD) that
significantly contributes to morbidity and mortality. In addition to clinical and life-style factors …