Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

The nodes of Ranvier have clustered Na+ and K+ channels necessary for rapid and efficient
axonal action potential conduction. However, detailed mechanisms of channel clustering …

The axon initial segment (AIS) is a specialized membrane region in the axon of neurons
where action potentials are initiated. Crucial to the function of the AIS is the presence of …

Ion channel clustering at the axon initial segment (AIS) and nodes of Ranvier has been
suggested to be a key evolutionary innovation that enabled the development of the complex …

Action potential (AP) propagation in myelinated nerves requires clustered voltage gated
sodium and potassium channels. These channels must be specifically localized to nodes of …

Timely delivery of information is essential for proper functioning of the nervous system.
Precise regulation of nerve conduction velocity is needed for correct exertion of motor skills …

AnkyrinG (ankG) is highly enriched in neurons at axon initial segments (AISs) where it
clusters Na+ and K+ channels and maintains neuronal polarity. How ankG becomes …

Saltatory conduction of action potentials along myelinated axons depends on the nodes of
Ranvier—small unmyelinated axonal domains where voltage-gated sodium channels are …

Ion channel function is fundamental to the existence of life. In metazoans, the coordinate
activities of voltage-gated Na+ channels underlie cellular excitability and control neuronal …

Discovery of disease-associated autoantibodies has transformed the clinical management of
a variety of neurological disorders. Detection of autoantibodies aids diagnosis and allows …