Jaks and STATs: biological implications
WJ Leonard, JJ O'Shea - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …
a wide array of cellular functions in the lympho-hematopoietic system. These factors …
The jak-STAT pathway
K Imada, WJ Leonard - Molecular immunology, 2000 - Elsevier
A variety of important cellular functions are regulated by cytokines. The Jak-STAT pathway is
one of the important signaling pathways downstream of cytokine receptors. Following …
one of the important signaling pathways downstream of cytokine receptors. Following …
Structure, function, and regulation of STAT proteins
CP Lim, X Cao - Molecular biosystems, 2006 - pubs.rsc.org
The Signal Transducer and Activator of Transcription (STAT) family of proteins was first
discovered in the 1990's as key proteins in cytokine signaling. Since then, the field has …
discovered in the 1990's as key proteins in cytokine signaling. Since then, the field has …
STAT proteins and transcriptional responses to extracellular signals
CM Horvath - Trends in biochemical sciences, 2000 - cell.com
Signal transducer and activator of transcription (STAT) transcription factors are implicated in
programming gene expression in biological events as diverse as embryonic development …
programming gene expression in biological events as diverse as embryonic development …
[HTML][HTML] Fetal anemia and apoptosis of red cell progenitors in Stat5a−/− 5b−/− mice: a direct role for Stat5 in Bcl-XL induction
M Socolovsky, AEJ Fallon, S Wang, C Brugnara… - Cell, 1999 - cell.com
The erythropoietin receptor (EpoR) is essential for production of red blood cells; a principal
function of EpoR is to rescue committed erythroid progenitors from apoptosis. Stat5 is rapidly …
function of EpoR is to rescue committed erythroid progenitors from apoptosis. Stat5 is rapidly …
Immune response in Stat2 knockout mice
Type I IFNs induce gene expression through Stat1 and Stat2, which can in turn associate
either to form Stat1 homodimers or the transcription factor ISGF-3. Stat1 homodimers also …
either to form Stat1 homodimers or the transcription factor ISGF-3. Stat1 homodimers also …
STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene
N Kiuchi, K Nakajima, M Ichiba, T Fukada… - The Journal of …, 1999 - rupress.org
The signal transducers and activators of transcription (STAT) family members have been
implicated in regulating the growth, differentiation, and death of normal and transformed …
implicated in regulating the growth, differentiation, and death of normal and transformed …
Negative regulation of cytokine signaling pathways
H Yasukawa, A Sasaki… - Annual review of …, 2000 - annualreviews.org
The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate
cellular processes involved in cell growth, differentiation, and transformation through their …
cellular processes involved in cell growth, differentiation, and transformation through their …
Signal transducer and activator of transcription proteins in leukemias
M Benekli, MR Baer, H Baumann… - Blood, The Journal of …, 2003 - ashpublications.org
Signal transducer and activator of transcription (STAT) proteins are a 7-member family of
cytoplasmic transcription factors that contribute to signal transduction by cytokines …
cytoplasmic transcription factors that contribute to signal transduction by cytokines …
Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation
ABSTRACT STAT (signal transducers and activators of transcription) proteins are
transcription factors which are activated by phosphorylation on tyrosine residues upon …
transcription factors which are activated by phosphorylation on tyrosine residues upon …