Direct evidence gap on fixed versus adjusted‐dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: Systematic review and individual …
A Ciapponi, F Barreira, L Perelli… - Tropical Medicine & …, 2023 - Wiley Online Library
Objectives To determine the comparative efficacy and safety of a fixed dose of benznidazole
(BZN) with an adjusted‐dose for Trypanosoma cruzi‐seropositive adults without …
(BZN) with an adjusted‐dose for Trypanosoma cruzi‐seropositive adults without …
Fixed vs adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: a systematic review and meta-analysis
A Ciapponi, F Barreira, L Perelli… - PLoS neglected …, 2020 - journals.plos.org
Chagas disease is a neglected disease that remains a public health threat, particularly in
Latin America. The most important treatment options are nitroimidazole derivatives, such as …
Latin America. The most important treatment options are nitroimidazole derivatives, such as …
Structure‐based design, optimization of lead, synthesis, and biological evaluation of compounds active against Trypanosoma cruzi
GC de Almeida, GB de Oliveira… - Chemical Biology & …, 2023 - Wiley Online Library
Chagas' disease affects approximately eight million people throughout the world, especially
the poorest individuals. The protozoan that causes this disease–Trypanosoma cruzi–has the …
the poorest individuals. The protozoan that causes this disease–Trypanosoma cruzi–has the …
Sensitivity analysis for causality in observational studies for regulatory science
Objective: The United States Congress passed the 21st Century Cures Act mandating the
development of Food and Drug Administration guidance on regulatory use of real-world …
development of Food and Drug Administration guidance on regulatory use of real-world …