Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Directional cell migration normally relies on a variety of external signals, such as chemical,
mechanical, or electrical, which instruct cells in which direction to move. Many of the major …

Immune responses rely on the rapid and coordinated migration of leukocytes. Whereas it is
well established that single-cell migration is often guided by gradients of chemokines and …

Migration of leukocytes is essential for the induction, maintenance, and regulation of
immune responses. On their trafficking routes, leukocytes encounter microenvironments of …

G‐protein–coupled receptor (GPCR) signaling is essential for the spatiotemporal control of
leukocyte dynamics during immune responses. For efficient navigation through mammalian …

Effector T cells leave the lymph nodes armed with specialized functional attributes. Their
antigenic targets may be located anywhere in the body, posing the ultimate challenge: how …

Fabricating a porous scaffold with high surface area has been a major strategy in the tissue
engineering field. Among the many fabrication methods, electrospinning has become one of …

For eukaryotic cells to heal wounds, respond to immune signals, or metastasize, they must
migrate, often by adhering to extracellular matrix (ECM). Cells may also deposit ECM …

Chemokines have two types of interactions that function cooperatively to control cell
migration. Chemokine receptors on migrating cells integrate signals initiated upon …

Chemokine signaling is essential for coordinated cell migration in health and disease to
specifically govern cell positioning in space and time. Typically, chemokines signal through …