HIV infection: epidemiology, pathogenesis, treatment, and prevention

G Maartens, C Celum, SR Lewin - The Lancet, 2014 - thelancet.com
HIV prevalence is increasing worldwide because people on antiretroviral therapy are living
longer, although new infections decreased from 3· 3 million in 2002, to 2· 3 million in 2012 …

Astrocytes are active players in cerebral innate immunity

C Farina, F Aloisi, E Meinl - Trends in immunology, 2007 - cell.com
Innate immunity is a constitutive component of the central nervous system (CNS) and relies
strongly on resident myeloid cells, the microglia. However, evidence is emerging that the …

The structural basis of accelerated host cell entry by SARS‐CoV‐2

M Seyran, K Takayama, VN Uversky… - The FEBS …, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of
the pandemic coronavirus disease 2019 (COVID‐19) that exhibits an overwhelming …

HIV infects astrocytes in vivo and egresses from the brain to the periphery

V Lutgen, SD Narasipura, HJ Barbian… - PLoS …, 2020 - journals.plos.org
HIV invades the brain during acute infection. Yet, it is unknown whether long-lived infected
brain cells release productive virus that can egress from the brain to re-seed peripheral …

Virus glycosylation: role in virulence and immune interactions

DJ Vigerust, VL Shepherd - Trends in microbiology, 2007 - cell.com
The study of N-linked glycosylation as it relates to virus biology has become an area of
intense interest in recent years due to its ability to impart various advantages to virus survival …

HIV infection of non-classical cells in the brain

A Wahl, L Al-Harthi - Retrovirology, 2023 - Springer
HIV-associated neurological disorders (HAND) affect up to 50% of people living with HIV
(PLWH), even in the era of combination antiretroviral therapy (cART). HIV-DNA can be …

Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions

S Valdebenito, S Malik, R Luu, O Loudig, M Mitchell… - Scientific reports, 2021 - nature.com
Cell-to-cell communication is essential for the development and proper function of
multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) …

Cellular reservoirs of HIV-1 and their role in viral persistence

A Alexaki, Y Liu, B Wigdahl - Current HIV research, 2008 - ingentaconnect.com
A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of
the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can …

HIV-1 target cells in the CNS

SB Joseph, KT Arrildt, CB Sturdevant… - Journal of …, 2015 - Springer
HIV-1 replication in the central nervous system (CNS) is typically limited by the availability of
target cells. HIV-1 variants that are transmitted and dominate the early stages of infection …

Doxorubicin-loaded nanoparticles consisted of cationic-and mannose-modified-albumins for dual-targeting in brain tumors

HJ Byeon, S Lee, SY Min, ES Lee, BS Shin… - Journal of controlled …, 2016 - Elsevier
Albumin nanoparticles have been increasingly viewed as an effective way of delivering
chemotherapeutics to solid tumors. Here, we report the one-pot development of a unique …