After endocytosis, most membrane proteins and lipids return to the cell surface, but some
membrane components are delivered to late endosomes or the Golgi. We now understand …

Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the
presence of a phospholipid-binding motif—the PX domain. The ability of these proteins to …

Two endosome populations involved in recycling of membranes and receptors to the plasma
membrane have been described, the early and the recycling endosome. However, this …

The molecular mechanisms underlying early/recycling endosomes-to-TGN transport are still
not understood. We identified interactions between the TGN-localized putative t-SNAREs …

The excessive generation and accumulation of 40-and 42-aa β-amyloid peptides
(Aβ40/Aβ42) in selectively vulnerable brain regions is a major neuropathological feature of …

Retrograde transport, in which proteins and lipids are shuttled between endosomes and
biosynthetic/secretory compartments such as the Golgi apparatus, is crucial for a diverse …

The trans Golgi network (TGN) of plant cells sorts and packages Golgi products into
secretory (SV) and clathrin‐coated (CCV) vesicles. We have analyzed of TGN cisternae in …

Endocytosis is characterized by vesicular transport along numerous pathways. Common
steps in each pathway include membrane budding to form vesicles, transport to a particular …

Our view of biological membranes has evolved dramatically over the last few decades. In the
bilayer model from Singer & Nicholson (Science 1972; 175: 720–731), both proteins and …

Formation of mature excitatory synapses requires the assembly and delivery of NMDA
receptors to the neuronal plasma membrane. A key step in the trafficking of NMDA receptors …