Mechanisms of deep brain stimulation

TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?

RC Helmich, M Hallett, G Deuschl, I Toni, BR Bloem - Brain, 2012 - academic.oup.com
Tremor in Parkinson's disease has several mysterious features. Clinically, tremor is seen in
only three out of four patients with Parkinson's disease, and tremor-dominant patients …

[HTML][HTML] Local field potentials in Parkinson's disease: a frequency-based review

Z Yin, G Zhu, B Zhao, Y Bai, Y Jiang… - Neurobiology of …, 2021 - Elsevier
Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …

[HTML][HTML] The pathophysiology of Parkinson's disease tremor

MF Dirkx, M Bologna - Journal of the Neurological Sciences, 2022 - Elsevier
Tremor is one of the primary motor symptoms of Parkinson's disease (PD), and it is
characterized by a highly phenomenological heterogeneity. Clinical and experimental …

What brain signals are suitable for feedback control of deep brain stimulation in Parkinson's disease?

S Little, P Brown - Annals of the New York Academy of …, 2012 - Wiley Online Library
Feedback control of deep brain stimulation (DBS) in Parkinson's disease has great potential
to improve efficacy, reduce side effects, and decrease the cost of treatment. In this, the timing …

Subthalamic span of β oscillations predicts deep brain stimulation efficacy for patients with Parkinson's disease

A Zaidel, A Spivak, B Grieb, H Bergman, Z Israel - Brain, 2010 - academic.oup.com
The significance of oscillations that characterize the subthalamic nucleus in Parkinson's
disease is still under debate. Here, we analysed the spectral and spatial characteristics of …

[HTML][HTML] A systematic review of local field potential physiomarkers in Parkinson's disease: from clinical correlations to adaptive deep brain stimulation algorithms

BCM van Wijk, RMA de Bie, M Beudel - Journal of neurology, 2023 - Springer
Deep brain stimulation (DBS) treatment has proven effective in suppressing symptoms of
rigidity, bradykinesia, and tremor in Parkinson's disease. Still, patients may suffer from …

[HTML][HTML] The clinical and electrophysiological investigation of tremor

G Deuschl, JS Becktepe, M Dirkx… - Clinical …, 2022 - Elsevier
The various forms of tremor are now classified in two axes: clinical characteristics (axis 1)
and etiology (axis 2). Electrophysiology is an extension of the clinical exam …

Closed-loop control of deep brain stimulation: a simulation study

S Santaniello, G Fiengo, L Glielmo… - IEEE Transactions on …, 2010 - ieeexplore.ieee.org
Deep brain stimulation (DBS) is an effective therapy to treat movement disorders including
essential tremor, dystonia, and Parkinson's disease. Despite over a decade of clinical …

Innovations in deep brain stimulation methodology

AA Kühn, J Volkmann - Movement Disorders, 2017 - Wiley Online Library
Deep brain stimulation is a powerful clinical method for movement disorders that no longer
respond satisfactorily to pharmacological management, but its progress has been hampered …