The β-ketoester structural motif continues to intrigue chemists with its electrophilic and
nucleophilic sites. Proven to be a valuable tool within organic synthesis, natural product, and …

Background: Monobactam antibiotics have been testified to demonstrate significant
antibacterial activity especially the treatment of infections by superbug microbes. Recently …

A one-pot efficient synthetic protocol is described for the synthesis of carbapenem chalcone
derivatives using AAPTMS@ MCM-41 heterogeneous catalyst. Various substituted aromatic …

The carbapenem (β‐lactam antibiotic) scaffold serves as a useful nucleophile in
organocatalytic diarylprolinol trimethylsilyl ether mediated α‐heterofunctionalization …

Herein, we report the development of a mild synthetic route towards novel minocycline
derivatives using the proline-catalyzed three-component Mannich reaction. The reaction …

Organocatalytic Mannich Reactions on a Carbapenem Core – Synthesis of Mannich Bases and
Bicyclic Diazanonanes - Cele - 2014 - European Journal of Organic Chemistry - Wiley Online …

Herein we disclose an efficient and experimentally straightforward method for the
stereoselective synthesis of a variety of α‐substituted Mannich salts. This direct three …

Herein, we report the development of mild, organocatalyzed routes to novel β-lactam
carbapenem derivatives through Michael type C single bond C bond forming reactions. The …

Carbapenem-resistant Enterobacteriaceae (CRE), a resistant group of gram-negative
bacteria, can produce carbapenemase, destroying carbapenem molecules and causing …

In 1971, two industrial groups reported using L-proline to catalyse the intramolecular aldol
reaction of a triketone (known as the Hajos–Parrish–Eder–Sauer–Wiechert reaction) …