During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

Stem cells respond to nanoscale surface features, with changes in cell growth and
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

Phase separation of substrates and effectors is proposed to enhance biological reaction
rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching …

Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …

Oocytes accumulate maternal stores (proteins, mRNAs, metabolites, etc.) during their growth
in the ovary to support development after fertilization. To preserve this cytoplasmic maternal …

INTRODUCTION Mammalian embryos frequently develop abnormally, resulting in
miscarriages and genetic disorders such as Down syndrome. The major cause for aberrant …

Oocyte maturation, fertilization, and early embryonic development occur in the absence of
gene transcription. Therefore, it is critical to understand at a global level the post …

For more than 15 years, TPX2 has been studied as a factor critical for mitosis and spindle
assembly. These functions of TPX2 are attributed to its Ran-regulated microtubule …

The ability to reproduce relies in most eukaryotes on specialized cells called gametes.
Gametes are formed by the process of meiosis in which, after a single round of replication …