Thyroid gland organogenesis results in an organ the shape, size, and position of which are
largely conserved among adult individuals of the same species, thus suggesting that genetic …

Identification of the thyroid transcription factors (TTFs), NKX2-1, FOXE1, PAX8 and HHEX,
has considerably advanced our understanding of thyroid development, congenital thyroid …

During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the
three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo …

Our understanding of myeloid factors has been brought about we will focus on how
alteration of myeloid transcription by a number of different methods. Initially, myeloid factors …

Genetic analysis, embryonic tissue explantation and in vivo chromatin studies have together
identified the distinct regulatory steps that are necessary for the development of endoderm …

The homeobox gene Hex is expressed in the anterior visceral endoderm (AVE) and rostral
definitive endoderm of early mouse embryos. Later, Hex transcripts are detected in liver …

The divergent homeobox gene Hex exhibits three notable expression patterns during early
mouse development. Initially Hex is expressed in the primitive endoderm of the implanting …

Little is known about the mechanism by which embryonic liver, lung, and pancreas
progenitor cells emerge from the endodermal epithelium to initiate organogenesis …

Epigenetic studies are commonly conducted on DNA from tissue samples. However, tissues
are ensembles of cells that may each have their own epigenetic profile, and therefore inter …

In animal development, digestive tissues emerge from different positions of the endoderm as
a result of patterning signals from overlying mesoderm. Although embryonic tissue …