Background Malignancies are molecularly complex and become more resistant with each
line of therapy. We hypothesized that offering matched, individualized combination therapies …

Abstract Purpose In 2016, the University of Munich Molecular Tumor Board (MTB) was
implemented to initiate a precision oncology program. This review of cases was conducted …

Background and purpose In this manuscript we describe the academic French multicentric
molecular analysis platforms including PROFILER, promoted by Centre Léon Berard, and …

Introduction Considering the growing interest in matched cancer treatment, our aim was to
evaluate the ability of a comprehensive genomic profiling (CGP) assay to propose at least …

Background The benefit of precision medicine based on relatively limited gene sets and
often-archived samples remains unproven. PERMED-01 (NCT02342158) was a prospective …

Background An increasing number of trials indicate that treatment outcomes in cancer
patients with metastatic disease are improved when targeted treatments are matched with …

Background and purpose In Norway, comprehensive molecular tumour profiling is
implemented as part of the public healthcare system. A substantial number of tumours …

Abstract Introduction Whole Exome Sequencing (WES) has emerged as an efficient tool in
clinical cancer diagnostics to broaden the scope from panel-based diagnostics to screening …

Abstract Model-informed drug development involves developing and applying exposure-
based, biological, and statistical models derived from preclinical and clinical data sources to …

Symptomatic brain metastases (BM) are a frequent and late complication in cancer patients.
However, a subgroup of cancer patients presents with BM as the first symptom of metastatic …