Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …

A systematic literature review was undertaken to determine if conditioned pain modulation
(CPM) is reliable. Longitudinal, English language observational studies of the repeatability …

Preclinical studies coupled with clinical pharmacologic and neuroimaging investigations
have advanced our understanding of brain circuits that modulate pain. Descending pain …

The reviewed literature refines the methodology used for eliciting CPM responses and
characterizing their physiological attributes in healthy individuals and pain patients, and …

Conditioned pain modulation (CPM) is a centrally processed measure of the net effect of the
descending pain pathway. This comprises both the facilitatory as well as the inhibitory effect …

Objectives The primary aim was to assess the psychometric properties (including internal
consistency, construct validity, reproducibility, and factor structure) of the Central …

Descending controls, comprising pathways that originate in midbrain and brainstem regions
and project onto the spinal cord, have long been recognised as key links in the multiple …

Although fibromyalgia (FM) is associated with a deficit in inhibitory conditioned pain
modulation (CPM), the discriminative power of CPM procedures is unknown. Moreover, the …

Accumulating evidence reveal important applications of endogenous pain modulation
assessment in healthy controls and in patients in clinical settings, as dysregulations in the …

The purpose of this investigation was to identify modifiable risk factors for the development
of first-onset chronic neck pain among an inception cohort of healthy individuals working in a …