Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …

TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

The effects of fasting-mimicking diet (FMD) cycles in reducing many aging and disease risk
factors indicate it could affect Alzheimer's disease (AD). Here, we show that FMD cycles …

Dysregulation of neural stem cells (NSCs) is associated with several neurodevelopmental
disorders, including epilepsy and autism spectrum disorder. The mammalian target of …

In this project we set up a human cell‐based DNTin vitro testing strategy that is based on test
methods with high readiness and data generated therefrom. The methods underwent afit‐for …

The presence of neural stem cells (NSCs) and the production of new neurons in the adult
brain have received great attention from scientists and the public because of implications to …

The mammalian target of rapamycin complex 1 (mTORC1) integrates signals important for
cell growth, and its dysregulation in neural stem cells (NSCs) is implicated in several …

Abstract mTOR is a serine/threonine kinase composed of multiple protein components.
Intracellular signaling of mTOR complexes is involved in many of physiological functions …

The mammalian Target of Rapamycin (mTOR) is a molecular complex equipped with kinase
activity which controls cell viability being key in the PI3K/PTEN/Akt pathway. mTOR acts by …

Tuberous sclerosis complex (TSC) is a model disorder for understanding brain development
because the genes that cause TSC are known, many downstream molecular pathways have …