Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …

Proteases play critical roles in virtually all biological processes, including proliferation, cell
death and survival, protein turnover, and migration. However, when dysregulated, these …

Despite its success in achieving the long-term survival of 10–30% of treated individuals,
immune therapy is still ineffective for most patients with cancer,. Many efforts are therefore …

Tumor-infiltrating myeloid cells contribute to the development of the immunosuppressive
tumor microenvironment. Myeloid cell expression of arginase 1 (ARG1) promotes a protumor …

Effector trogocytosis between malignant cells and tumor-specific cytotoxic T lymphocytes
(CTLs) contributes to immune evasion through antigen loss on target cells and fratricide of …

Background The BIRC5 gene encodes for the Survivin protein, which is a member of the
inhibitor of apoptosis family. Survivin is found in humans during fetal development, but …

The ability of tumour cells to thrive in harsh microenvironments depends on the utilization of
nutrients available in the milieu. Here we show that pancreatic cancer-associated fibroblasts …

The survival rate of colorectal cancer patients is adversely affected by the selection of tumors
resistant to conventional anti-cancer drugs such as 5-fluorouracil (5FU). Although there is …

Prognostic biomarkers are of great significance to predict the outcome of patients with
cancer, to guide the clinical treatments, to elucidate tumorigenesis mechanisms, and offer …

This study was initiated to explore the expression variation, clinical significance, and
biological importance of the GINS complex subunit 4 (GINS4) in different human cancers as …