In this review we examine techniques, software, and statistical analyses used in label‐free
quantitative proteomics studies for area under the curve and spectral counting approaches …

Spectral count, defined as the total number of spectra identified for a protein, has gained
acceptance as a practical, label-free, semiquantitative measure of protein abundance in …

The intestinal microbiota is known to regulate host energy homeostasis and can be
influenced by high-calorie diets. However, changes affecting the ecosystem at the functional …

Glandular trichomes are metabolic cell factories with the capacity to produce large quantities
of secondary metabolites. Little is known about the connection between central carbon …

A volcano plot displays unstandardized signal (eg log-fold-change) against noise-
adjusted/standardized signal (eg t-statistic or-log10 (p-value) from the t-test). We review the …

Patients with depression often suffer from cognitive impairments that contribute to disease
burden. We used social defeat–induced persistent stress (SDPS) to induce a depressive-like …

Abstract Background The United States is currently facing an opioid crisis. Novel tools to
better comprehend dynamic molecular changes in the brain associated with the opioid …

Nitrogen fixation rates of the globally distributed, biogeochemically important marine
cyanobacterium Trichodesmium increase under high carbon dioxide (CO2) levels in short …

To identify new molecular targets of rapamycin, an anticancer and immunosuppressive drug,
we analyzed temporal changes in yeast over 6 h in response to rapamycin at the …

If the large collection of microarray-specific statistical tools was applicable to the analysis of
quantitative shotgun proteomics datasets, it would certainly foster an important advancement …