Ribosome biogenesis in disease: new players and therapeutic targets

L Jiao, Y Liu, XY Yu, X Pan, Y Zhang, J Tu… - … and Targeted Therapy, 2023 - nature.com
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

[HTML][HTML] Mannan-binding lectin via interaction with cell surface calreticulin promotes senescence of activated hepatic stellate cells to limit liver fibrosis progression

J Luo, L Li, B Chang, Z Zhu, F Deng, M Hu, Y Yu… - Cellular and Molecular …, 2022 - Elsevier
Background & Aims Liver fibrosis represents a hallmark of most chronic liver diseases (CLD)
triggered by recurrent liver injury and subsequent myofibroblast transdifferentiations of …

The inflamm-aging model identifies key risk factors in atherosclerosis

Y He, Y Chen, L Yao, J Wang, X Sha, Y Wang - Frontiers in Genetics, 2022 - frontiersin.org
Background: Atherosclerosis, one of the main threats to human life and health, is driven by
abnormal inflammation (ie, chronic inflammation or oxidative stress) during accelerated …

Ergosterol peroxide inhibits porcine epidemic diarrhea virus infection in vero cells by suppressing ROS generation and p53 activation

Y Liu, X Wang, J Wang, J Zhang, C Duan, J Wang - Viruses, 2022 - mdpi.com
Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus that causes severe watery
diarrhea in piglets with high morbidity and mortality, resulting in serious economic losses to …

[HTML][HTML] Amarogentin inhibits vascular smooth muscle cell proliferation and migration and attenuates neointimal hyperplasia via AMPK activation

F Jia, R Ji, G Qiao, Z Sun, X Chen, Z Zhang - Biochimica et Biophysica Acta …, 2023 - Elsevier
Objectives Recent studies validated the expression of extraoral bitter taste receptors and
established the importance of regulatory functions that are associated with various cellular …

BOP1 Used as a Novel Prognostic Marker and Correlated with Tumor Microenvironment in Pan‐Cancer

W Li, P Song, M Zhao, L Gao, J Xie… - Journal of Oncology, 2021 - Wiley Online Library
Previous studies have indicated the important role of block of proliferation 1 (BOP1) in the
progression of several malignant tumors; no comprehensive pan‐cancer analysis of BOP1 …

Identification of key differentially methylated genes in regulating muscle development and intramuscular fat deposition in chickens

B Yu, Z Cai, J Liu, T Zhang, X Feng, C Wang, J Li… - International Journal of …, 2024 - Elsevier
Muscle development and intramuscular fat (IMF) deposition are intricate physiological
processes characterized by multiple gene expressions and interactions. In this research, the …

Glut10 restrains neointima formation by promoting SMCs mtDNA demethylation and improving mitochondrial function

Q Wu, Z Hu, Z Wang, Y Che, M Zhang, S Zheng… - Translational …, 2023 - Elsevier
Neointimal hyperplasia is a major clinical complication of coronary artery bypass graft and
percutaneous coronary intervention. Smooth muscle cells (SMCs) play a vital roles in …

CIRC_0091822 CONTRIBUTES TO THE PROLIFERATION, INVASION, AND MIGRATION OF VASCULAR SMOOTH MUSCLE CELLS UNDER OXIDIZED LOW …

H Sun, X Huang, S Hong - Shock, 2023 - journals.lww.com
Background: Circular RNAs (circRNAs) have been shown to mediate atherosclerosis (AS)
process by regulating vascular smooth muscle cells (VSMCs) function. However, whether …

Investigating WDR12 as a Therapeutic Target in Breast Cancer

JS Kim - 2023 - search.proquest.com
Breast cancer is the most diagnosed and lethal cancer globally in women. Presently, there is
a need for novel targets for the development of improved therapeutics. Data mining through …