Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …

The extracellular matrix (ECM) is an important component of the tumor microenvironment
(TME), having several important roles related to the hallmarks of cancer. In cancer, multiple …

The tumor micro-environment often contains stiff and irregular-bundled collagen fibers that
are used by tumor cells to disseminate. It is still unclear how and to what extent, extracellular …

The epithelial-mesenchymal transition (EMT) is required in the embryo for the formation of
tissues for which cells originate far from their final destination. Carcinoma cells hijack this …

The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of
evidence implicating the tumour microenvironment as pivotal in all aspects of tumour …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Background The incidence and mortality rates of hepatocellular carcinoma (HCC) have
steadily increased in recent years. A hypoxic microenvironment is one of the most important …

Purpose: Bone marrow–derived progenitor cells, including VEGFR2+ endothelial progenitor
cells (EPCs) and copper-dependent pathways, model the tumor microenvironment. We …

Increased attention is paid to the structural components of tissues. These components are
mostly collagens and various proteoglycans. Emerging evidence suggests that altered …

The epithelial to mesenchymal transition or EMT has become one of the most exciting fields
in cancer research. Nevertheless, its relevance in tumor biology and the metastatic process …