Adipose tissue at single-cell resolution
Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …
composition under physiological and pathophysiological conditions. The emergence of …
Microglia regulation of central nervous system myelin health and regeneration
SA Kent, VE Miron - Nature Reviews Immunology, 2023 - nature.com
Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …
its development, homeostasis and response to damage and infection. Although microglia …
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases
Identification of therapeutic targets from genome-wide association studies (GWAS) requires
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain
The relationship between genetic variation and gene expression in brain cell types and
subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data …
subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data …
Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects
Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during
REM sleep, is an early clinical symptom of alpha-synucleinopathies and defines a more …
REM sleep, is an early clinical symptom of alpha-synucleinopathies and defines a more …
PICALM and Alzheimer's disease: an update and perspectives
K Ando, S Nagaraj, F Küçükali, MA De Fisenne… - Cells, 2022 - mdpi.com
Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol
binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus …
binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus …
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
Methods and insights from single-cell expression quantitative trait loci
Recent advancements in single-cell technologies have enabled expression quantitative trait
locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk …
locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk …
Roles and regulation of microglia activity in multiple sclerosis: insights from animal models
F Distéfano-Gagné, S Bitarafan, S Lacroix… - Nature Reviews …, 2023 - nature.com
As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …
[PDF][PDF] Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer's disease-specific cis-regulatory elements
AG Anderson, BB Rogers, JM Loupe… - Cell Genomics, 2023 - cell.com
Cell type-specific transcriptional differences between brain tissues from donors with
Alzheimer's disease (AD) and unaffected controls have been well documented, but few …
Alzheimer's disease (AD) and unaffected controls have been well documented, but few …