In neurons, Glycogen Synthase Kinase‐3β (GSK‐3β) has been shown to regulate various
critical processes underlying structural and functional synaptic plasticity. Mouse models with …

Objective: Despite effective pharmacological treatments for bipolar disorder, we still lack a
comprehensive pathophysiological model of the illness. Recent neurobiological research …

Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

Dopamine D2 receptor antagonism is a unifying property of all antipsychotic drugs in clinical
use. Remarkably, the effector molecules through which these medications exert their actions …

Objective: Attention deficit hyperactivity disorder (ADHD) is a highly heritable
neuropsychiatric disorder. In the present study, the authors investigated the presence of …

Abstract Glycogen synthase kinase 3 (GSK3) has been identified as a promising target for
the treatment of Alzheimer's disease (AD), where abnormal activation of this enzyme has …

During development of the central nervous system the Wnt signaling pathway has been
implicated in a wide spectrum of physiological processes, including neuronal connectivity …

Schizophrenia-related psychosis is associated with disturbances in mesolimbic dopamine
(DA) transmission, characterized by hyperdopaminergic activity in the mesolimbic pathway …

In order to function properly, the brain must be wired correctly during critical periods in early
development. Mistakes in this process are hypothesized to occur in disorders like autism …

Converging evidence suggests that the regulation of glycogen synthase kinase 3 (GSK-3)
might be important in schizophrenia. Atypical and typical antipsychotic drugs alter GSK-3 …