DA Cousins, K Butts, AH Young - Bipolar disorders, 2009 - Wiley Online Library
Objective: Despite effective pharmacological treatments for bipolar disorder, we still lack a comprehensive pathophysiological model of the illness. Recent neurobiological research …
A de Bartolomeis, L Vellucci, A Barone… - Pharmacology & …, 2022 - Elsevier
Almost fifty years after its first introduction into clinical care, clozapine remains the only evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …
Z Freyberg, SJ Ferrando… - American Journal of …, 2010 - Am Psychiatric Assoc
Dopamine D2 receptor antagonism is a unifying property of all antipsychotic drugs in clinical use. Remarkably, the effector molecules through which these medications exert their actions …
G Poelmans, DL Pauls, JK Buitelaar… - American Journal of …, 2011 - Am Psychiatric Assoc
Objective: Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric disorder. In the present study, the authors investigated the presence of …
Abstract Glycogen synthase kinase 3 (GSK3) has been identified as a promising target for the treatment of Alzheimer's disease (AD), where abnormal activation of this enzyme has …
During development of the central nervous system the Wnt signaling pathway has been implicated in a wide spectrum of physiological processes, including neuronal connectivity …
J Renard, M Loureiro, LG Rosen, J Zunder… - Journal of …, 2016 - Soc Neuroscience
Schizophrenia-related psychosis is associated with disturbances in mesolimbic dopamine (DA) transmission, characterized by hyperdopaminergic activity in the mesolimbic pathway …
In order to function properly, the brain must be wired correctly during critical periods in early development. Mistakes in this process are hypothesized to occur in disorders like autism …
Converging evidence suggests that the regulation of glycogen synthase kinase 3 (GSK-3) might be important in schizophrenia. Atypical and typical antipsychotic drugs alter GSK-3 …