Glioblastoma is a unique model of non-metastasising disease that kills the vast majority of
patients through local growth, despite surgery and local irradiation. Glioblastoma cells are …

Autophagy is used by organisms as a defense strategy to face environmental stress. This
mechanism has been described as one of the most important intracellular pathways …

Autophagy plays important roles in modulating viral replication and antiviral immune
response. Coronavirus infection is associated with the autophagic process, however, little is …

Ethanol-induced hepatic steatosis may induce the progression of alcoholic liver disease.
The involvement of autophagic clearance of damaged mitochondria (mitophagy) and lipid …

Autophagy is a molecular process essential for the maintenance of cellular homeostasis,
which appears to (i) decline with age and (ii) respond to physical exercise. In addition …

Key message The genes coding for wheat ATG4 and ATG8 were cloned and their roles in
autophagy were verified. Implications of ATG4/ATG8 in wheat responses to stresses were …

The mounting number of patients with pulmonary adenocarcinoma (ADCA) is subjected to
poor prognosis and heavy mortality, which prompts us to explore new potential therapeutics …

Abstract Spinocerebellar ataxia type 7 (SCA7) is one of nine neurodegenerative disorders
caused by expanded polyglutamine domains. These so-called polyglutamine (polyQ) …

Background: Activation of wild-type p53 with the small molecule sirtuin inhibitor Tenovin-6
(Tnv-6) induces p53-dependent apoptosis in many malignant cells. In contrast, Tnv-6 …

Autophagy is an essential homeostatic process by which cytoplasmic components, including
macromolecules and organelles, are degraded by lysosome. Increasing evidence suggests …