Articular cartilage has a limited capacity to repair following injury. Early intervention is
required to prevent progression of focal traumatic chondral and osteochondral defects to …

Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of
cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and …

OBJECTIVE: Three-dimensional (3D) cultures are widely used to redifferentiate
chondrocytes. However, the rationale behind the choice for 3D above two-dimensional (2D) …

Autologous chondrocyte implantation is being used increasingly for the treatment of
cartilage defects. In spite of this, there has been a paucity of objective, standardised …

Chondrocyte is a unique cell type in articular cartilage tissue and is essential for cartilage
formation and functionality. It arises from mesenchymal stem cells (MSCs) and is regulated …

Disc degeneration is a common disorder. Although the back pain that can develop in
association with this is rarely life-threatening, the annual cost in terms of morbidity, lost …

Autologous chondrocyte implantation (ACI) has been used most commonly as a treatment
for cartilage defects in the knee and there are few studies of its use in other joints. We …

PURPOSE: To evaluate magnetic resonance (MR) imaging features of autologous
chondrocyte implantation (ACI) grafts and compare these with graft histologic features 1 year …

Gene therapy is a promising method for osteoarthritis and cartilage injury. However,
specifically delivering target genes into chondrocytes is a great challenge because of their …

Abstract Hypoxia-inducible factor-2α (Hif-2α) is a potential therapeutic target for
osteoarthritis (OA), but the application of this target in the delivery of therapeutic agents to …