Histone modifications and RNA splicing, two seemingly unrelated gene regulatory
processes, greatly increase proteome diversity and profoundly influence normal as well as …

Alternative splicing represents an important level of the regulation of gene function in
eukaryotic organisms. It plays a critical role in virtually every biological process within an …

The introduction of insertion-deletions (INDELs) by non-homologous end-joining (NHEJ)
pathway underlies the mechanistic basis of CRISPR-Cas9-directed genome editing …

It is generally believed that splicing removes introns as single units from precursor
messenger RNA transcripts. However, some long Drosophila melanogaster introns contain …

Multiplex assays of variant effect (MAVEs) are a family of methods that includes deep
mutational scanning experiments on proteins and massively parallel reporter assays on …

Alternative splicing is regulated by RNA binding proteins (RBPs) that recognize pre-mRNA
sequence elements and activate or repress adjacent exons. Here, we used RNA …

Recent advances in long-read sequencing solve inaccuracies in alternative transcript
identification of full-length transcripts in short-read RNA-Seq data, which encourages the …

Inflammatory myofibroblastic tumors (IMTs) are characterized by myofibroblast proliferation
and an inflammatory cell infiltrate. Little is known about the molecular pathways that …

Non-alcoholic fatty liver disease (NAFLD) is associated with human environmental exposure
to polychlorinated biphenyls (PCBs). Alternative splicing (AS) is dysregulated in steatotic …

Alternative splicing is an important step in eukaryotic mRNA pre-processing which increases
the complexity of gene expression programs, but is frequently altered in disease. Previous …