UV-induced skin damage

M Ichihashi, M Ueda, A Budiyanto, T Bito, M Oka… - Toxicology, 2003 - Elsevier
Solar radiation induces acute and chronic reactions in human and animal skin. Chronic
repeated exposures are the primary cause of benign and malignant skin tumors, including …

Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells

J Boonstra, JA Post - Gene, 2004 - Elsevier
Cell cycle progression is regulated by a wide variety of external factors, amongst them are
growth factors and extracellular matrix factors. During the last decades evidence has been …

Ultraviolet‐B irradiation and matrix metalloproteinases: from induction via signaling to initial events

P Brenneisen, H Sies… - Annals of the New …, 2002 - Wiley Online Library
Effects of sunlight have fascinated researchers for decades because nearly every living
thing on earth is likely to be exposed to sunlight and the ultraviolet (UV) fraction of it. In …

Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis

CS Sander, H Chang, F Hamm… - International journal …, 2004 - Wiley Online Library
Melanoma and nonmelanoma skin cancers are among the most prevalent cancers in the
human population. Solar ultraviolet radiation is considered a major etiological factor but the …

The molecular pathology of rosacea

K Yamasaki, RL Gallo - Journal of dermatological science, 2009 - Elsevier
Rosacea is a common and chronic inflammatory skin disease that affects over 10 million
Americans. Although the phenotypes of rosacea are clinically heterogeneous, they are all …

Photochemoprevention of ultraviolet B signaling and photocarcinogenesis

F Afaq, VM Adhami, H Mukhtar - Mutation Research/Fundamental and …, 2005 - Elsevier
Exposure to solar radiation, particularly its ultraviolet (UV) B component, has a variety of
harmful effects on human health. Some of these effects include sunburn cell formation, basal …

The UV response of the skin: a review of the MAPK, NFκB and TNFα signal transduction pathways

V Muthusamy, TJ Piva - Archives of dermatological research, 2010 - Springer
The sun emits different types of ultraviolet (UV) light. Our skin is a natural target of UV
radiation which is involved in vitamin D 3 production in our body. UV radiation at high doses …

Cutaneous effects of infrared radiation: from clinical observations to molecular response mechanisms

SM Schieke, P Schroeder… - Photodermatology …, 2003 - Wiley Online Library
Human skin is exposed to infrared (IR) radiation (760 nm–1 mm) from natural as well as
artificial sources that are increasingly used for cosmetic or medical purposes …

p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice

G Ramesh, WB Reeves - American Journal of Physiology …, 2005 - journals.physiology.org
Cisplatin is an important chemotherapeutic agent but can cause acute renal injury. Part of
this acute renal injury is mediated through tumor necrosis factor-α (TNF-α). The pathway …

[HTML][HTML] Keratinocyte apoptosis in epidermal development and disease

D Raj, DE Brash, D Grossman - Journal of Investigative Dermatology, 2006 - Elsevier
Keratinocyte (KC) apoptosis plays a critical role in regulating epidermal development and
restraining carcinogenesis. Apoptosis balances proliferation to maintain epidermal …