• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Coronary computed tomography angiography (CTA) has shown great technological
improvements over the last 2 decades. High accuracy of CTA in detecting significant …

Background In patients with suspected obstructive coronary artery disease (CAD), the risk
factor–weighted clinical likelihood (RF-CL) model and the coronary artery calcium score …

Clinical and economic burdens exist within the coronary artery disease (CAD) care pathway
despite advances in diagnosis and treatment and the increasing utilization of percutaneous …

Coronary artery disease (CAD) continues to be the leading cause of mortality and morbidity
in developed countries. Assessment of pre-test probability (PTP) based on patient's …

Background Substantial differences exist between different guideline‐recommended pretest
probability (PTP) models for the detection of obstructive coronary artery disease (CAD). This …

Background Guidelines for evaluating patients with suspected coronary artery disease
(CAD) recommend pretest probability (PTP) estimation but provide no clear …

Background Coronary artery calcium scoring (CACS) improves management of chest pain
patients. However, it is unknown whether the benefit of CACS is dependent on the clinical …

Background High serum NEFA and GDF-15 are risk factors for CAD and have been linked to
detrimental cardiovascular events. It has been hypothesized that hyperuricemia causes CAD …

Background The risk assessment of patients with stable chest pain (SCP) to defer further
cardiovascular testing is crucial, but the most appropriate risk assessment strategy remains …