[HTML][HTML] An overview of chronic kidney disease pathophysiology: The impact of gut dysbiosis and oral disease

S Altamura, D Pietropaoli, F Lombardi, R Del Pinto… - Biomedicines, 2023 - mdpi.com
Chronic kidney disease (CKD) is a severe condition and a significant public health issue
worldwide, carrying the burden of an increased risk of cardiovascular events and mortality …

Therapeutic Potential of Mushrooms: A Review on NF-κB Modulation in Chronic Inflammation

NA Amirullah, E Abdullah, NZ Abidin, N Abdullah… - Food Bioscience, 2024 - Elsevier
Numerous mushroom species are valued not just for their flavor but also for their health
advantages. Historically, these mushrooms have been utilized for medicinal purposes …

Endoplasmic reticulum stress in systemic lupus erythematosus and lupus nephritis: potential therapeutic target

HY Li, LF Huang, XR Huang, D Wu… - Journal of …, 2023 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one‐
third to two‐thirds of the patients with SLE progress to lupus nephritis (LN). The …

[HTML][HTML] Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation

C Smith, R du Toit, T Ollewagen - Inflammopharmacology, 2023 - Springer
Up to 50% of systemic lupus erythematosus (SLE) patients world-wide develop lupus
nephritis (LN). In low to middle income countries and in particular in sub-Saharan Africa …

Macrophage polarization and signaling in diabetic kidney disease: a catalyst for disease progression

N Youssef, MH Noureldein, ME Riachi… - American Journal …, 2024 - journals.physiology.org
Diabetic kidney disease (DKD) is a serious complication of diabetes affecting millions of
people worldwide. Macrophages, a critical immune cell type, are central players in the …

[HTML][HTML] Localization of natriuretic peptide receptors A, B, and C in healthy and diseased mouse kidneys

ES Heinl, KAE Broeker, C Lehrmann, R Heydn… - … -European Journal of …, 2023 - Springer
The natriuretic peptides (NPs) ANP (atrial natriuretic peptide) and BNP (B-type natriuretic
peptide) mediate their widespread effects by activating the natriuretic peptide receptor-A …

Endothelial mechanical stretch regulates the immunological synapse interface of renal endothelial cells in a sex-dependent manner

CA Colvert, KP Hawkins… - American Journal …, 2023 - journals.physiology.org
Increased mechanical endothelial cell stretch contributes to the development of numerous
cardiovascular and renal pathologies. Recent studies have shone a light on the importance …

Shen-Shuai-II-Recipe inhibits tubular inflammation by PPARα-mediated fatty acid oxidation to attenuate fibroblast activation in fibrotic kidneys

M Wang, L Wang, L Zhou, Y Xu, C Wang - Phytomedicine, 2024 - Elsevier
Abstract Background Shen Shuai Ⅱ Recipe (SSR) is clinically used to treat chronic kidney
diseases (CKDs) with remarkable efficacy and safety. In earlier research, we found the anti …

[HTML][HTML] Innate Immunity and CKD: Is There a Significant Association?

M Plonsky-Toder, D Magen, S Pollack - Cells, 2023 - mdpi.com
Chronic kidney disease (CKD) constitutes a worldwide epidemic, affecting approximately
10% of the global population, and imposes significant medical, psychological, and financial …

[HTML][HTML] Increased cardiovascular risk in patients with chronic kidney disease

S Vondenhoff, SJ Schunk, H Noels - Herz, 2024 - Springer
Cardiovascular disease (CVD) is highly prevalent in patients suffering from chronic kidney
disease (CKD). The risk of patients with CKD developing CVD is manifested already in the …