TRAIL receptor-induced features of epithelial-to-mesenchymal transition increase tumour phenotypic heterogeneity: potential cell survival mechanisms

L Peyre, M Meyer, P Hofman, J Roux - British Journal of Cancer, 2021 - nature.com
The continuing efforts to exploit the death receptor agonists, such as the tumour necrosis
factor (TNF)-related apoptosis-inducing ligand (TRAIL), for cancer therapy, have largely …

Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability

JM Hope, M Lopez-Cavestany, W Wang… - Cell Death & …, 2019 - nature.com
TRAIL specifically induces apoptosis in cancer cells without affecting healthy cells. However,
TRAIL's cancer cytotoxicity was insufficient in clinical trials. Circulatory-shear stress is known …

Core models of receptor reactions to evaluate basic pathway designs enabling heterogeneous commitments to apoptosis

M Péré, M Chaves, J Roux - … 2020, Konstanz, Germany, September 23–25 …, 2020 - Springer
Isogenic cells can respond differently to cytotoxic drugs, such as the tumor necrosis factor-
related apoptosis inducing ligand (TRAIL), with only a fraction committing to apoptosis …

Modeling cell response heterogeneity to pro-apoptotic ligands

LCG Pereira - 2019 - theses.hal.science
Apoptosis is an essential physiological process through which organisms are able to
equilibrate their cell numbers and maintain tissues in healthy and functional conditions …

Modélisation de l'hétérogénéité de la réponse cellulaire aux ligands pro-apoptotiques

LCG Pereira - 2019 - theses.fr
à l'Université Côte d'Azur (ComUE), dans le cadre de École doctorale Sciences et
technologies de l'information et de la communication (Sophia Antipolis, Alpes-Maritimes), en …