Immune regulation is fundamental to any immune response to ensure that it is appropriate
for the perceived threat to the host. Following cell and organ transplantation, it is essential to …

Regulatory T (Treg) cells are essential for immunological tolerance and homeostasis.
Although forkhead box (Fox) p3 is continually required to reinforce the Treg cell program …

T‐regulatory cells (Tregs) have a fundamental role in the establishment and maintenance of
peripheral tolerance. There is now compelling evidence that deficits in the numbers and/or …

In a cross-sectional study, we assessed effects of calcineurin inhibitor (CNI) or rapamycin on
T-regulatory (Treg) cells from children with stable liver (n= 53) or kidney (n= 9) allografts …

Transplantation is the most effective treatment for end-stage organ failure, but organ survival
is limited by immune rejection and the side effects of immunosuppressive regimens. T cells …

The immune response to an allograft activates lymphocytes with the capacity to cause
rejection. Activation of CD4+ CD25+ Foxp3+ T regulatory cells (Treg) can down-regulate …

Currently, acute allograft rejection can only be detected reliably by deterioration of graft
function confirmed by allograft biopsy. A huge drawback of this method of diagnosis is that …

Human graft endothelial cells (ECs) can act as antigen-presenting cells to initiate allograft
rejection by host memory T cells. Rapamycin, an mTOR inhibitor used clinically to suppress …

Regulatory T cells (Tregs) are known to suppress alloimmune responses during pregnancy
and post organ transplantation. We demonstrate that a distinct subset of FoxP3+ DR+-Tregs …

Current clinical strategies to control the alloimmune response after transplantation do not
fully prevent induction of the immunological processes which lead to acute and chronic …