Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy

G Sloan, D Selvarajah, S Tesfaye - Nature Reviews Endocrinology, 2021 - nature.com
Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

Early detection of diabetic peripheral neuropathy: a focus on small nerve fibres

J Burgess, B Frank, A Marshall, RS Khalil, G Ponirakis… - Diagnostics, 2021 - mdpi.com
Diabetic peripheral neuropathy (DPN) is the most common complication of both type 1 and 2
diabetes. As a result, neuropathic pain, diabetic foot ulcers and lower-limb amputations …

Diagnosis of neuropathy and risk factors for corneal nerve loss in type 1 and type 2 diabetes: a corneal confocal microscopy study

M Ferdousi, A Kalteniece, S Azmi… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE To assess the diagnostic utility of corneal confocal microscopy (CCM) for
diabetic peripheral neuropathy (DPN) and the risk factors for corneal nerve loss …

Prevalence of peripheral neuropathy in pre-diabetes: a systematic review

V Kirthi, A Perumbalath, E Brown, S Nevitt… - BMJ Open Diabetes …, 2021 - drc.bmj.com
There is growing evidence of excess peripheral neuropathy in pre-diabetes. We aimed to
determine its prevalence, including the impact of diagnostic methodology on prevalence …

Artificial intelligence utilising corneal confocal microscopy for the diagnosis of peripheral neuropathy in diabetes mellitus and prediabetes

FG Preston, Y Meng, J Burgess, M Ferdousi, S Azmi… - Diabetologia, 2022 - Springer
Aims/hypothesis We aimed to develop an artificial intelligence (AI)-based deep learning
algorithm (DLA) applying attribution methods without image segmentation to corneal …

An artificial intelligence-based deep learning algorithm for the diagnosis of diabetic neuropathy using corneal confocal microscopy: a development and validation …

BM Williams, D Borroni, R Liu, Y Zhao, J Zhang, J Lim… - Diabetologia, 2020 - Springer
Aims/hypothesis Corneal confocal microscopy is a rapid non-invasive ophthalmic imaging
technique that identifies peripheral and central neurodegenerative disease. Quantification of …

Corneal confocal microscopy predicts the development of diabetic neuropathy: a longitudinal diagnostic multinational consortium study

BA Perkins, LE Lovblom, EJH Lewis, V Bril… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE Corneal nerve fiber length (CNFL) has been shown in research studies to
identify diabetic peripheral neuropathy (DPN). In this longitudinal diagnostic study, we …

Efficacy and safety of the combination of superoxide dismutase, alpha lipoic acid, vitamin B12, and carnitine for 12 months in patients with diabetic neuropathy

T Didangelos, E Karlafti, E Kotzakioulafi, Z Kontoninas… - Nutrients, 2020 - mdpi.com
Aim: To investigate the efficacy of Superoxide Dismutase, Alpha Lipoic Acid, Acetyl L-
Carnitine, and Vitamin B12 (B12) in one tablet in Diabetic Neuropathy (DN). Patients …

[HTML][HTML] Corneal confocal microscopy: a biomarker for diabetic peripheral neuropathy

IN Petropoulos, G Ponirakis, M Ferdousi, S Azmi… - Clinical …, 2021 - Elsevier
Purpose Diagnosing early diabetic peripheral neuropathy remains a challenge due to
deficiencies in currently advocated end points. The cornea is densely innervated with small …

Perspectives of glycemic variability in diabetic neuropathy: a comprehensive review

X Zhang, X Yang, B Sun, C Zhu - Communications biology, 2021 - nature.com
Diabetic neuropathy is one of the most prevalent chronic complications of diabetes, and up
to half of diabetic patients will develop diabetic neuropathy during their disease course …