The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …

The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to
fatal in others. Based on a study of 1,051,032 23andMe research participants, we report …

The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32)
allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in …

The recent increase in genomic data is revealing an unexpected perspective of gene loss as
a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This …

Prime editors (PEs) mediate genome modification without utilizing double-stranded DNA
breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or …

German Advisory Committee Blood (Arbeitskreis Blut), Subgroup 'Assessment of Pathogens
Transmissible by Blood'tein, TM) are derived. In addition to the structural proteins, the HIV …

Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

Experiments of nature have revealed the peculiar importance of the G-protein–coupled
receptor, CC chemokine receptor type 5 (CCR5), in human disease since ancient times. The …