ABC transporter research: going strong 40 years on
FL Theodoulou, ID Kerr - Biochemical Society Transactions, 2015 - portlandpress.com
In most organisms, ABC transporters constitute one of the largest families of membrane
proteins. In humans, their functions are diverse and underpin numerous key physiological …
proteins. In humans, their functions are diverse and underpin numerous key physiological …
The role of drug transporters in the kidney: lessons from tenofovir
Tenofovir disoproxil fumarate, the prodrug of nucleotide reverse transcriptase inhibitor
tenofovir, shows high efficacy and relatively low toxicity in HIV patients. However, long-term …
tenofovir, shows high efficacy and relatively low toxicity in HIV patients. However, long-term …
Pregnane X receptor (PXR) polymorphisms and cancer treatment
A Skandalaki, P Sarantis, S Theocharis - Biomolecules, 2021 - mdpi.com
Pregnane X Receptor (PXR) belongs to the nuclear receptors' superfamily and mainly
functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed …
functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed …
Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke
R Liu, Z Zhou, Y Chen, J Li, W Yu, X Chen… - Acta Pharmacologica …, 2016 - nature.com
Aim: There is a high incidence of the antiplatelet drug clopidogrel resistance (CR) in Asian
populations. Because clopidogrel is a prodrug, polymorphisms of genes encoding the …
populations. Because clopidogrel is a prodrug, polymorphisms of genes encoding the …
Comprehensive pharmacokinetic, pharmacodynamic and pharmacogenetic evaluation of once-daily efavirenz 400 and 600 mg in treatment-naive HIV-infected …
L Dickinson, J Amin, L Else, M Boffito, D Egan… - Clinical …, 2016 - Springer
Background ENCORE1 demonstrated non-inferiority of daily efavirenz 400 mg (EFV400)
versus 600 mg (EFV600) to 96 weeks in treatment-naïve, HIV-infected adults but concerns …
versus 600 mg (EFV600) to 96 weeks in treatment-naïve, HIV-infected adults but concerns …
Renal tubular transporter-mediated interactions of HIV drugs: implications for patient management.
F Gutierrez, X Fulladosa, G Barril… - AIDS reviews, 2014 - search.ebscohost.com
Interactions of drugs with renal transporters can reduce the tubular secretion of endogenous
products and affect drug pharmacokinetics, efficacy, and toxicity. This review aims to …
products and affect drug pharmacokinetics, efficacy, and toxicity. This review aims to …
Role of the lean body mass and of pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of sunitinib in cancer patients
C Narjoz, A Cessot, A Thomas-Schoemann… - Investigational new …, 2015 - Springer
Introduction Sunitinib is a multikinase inhibitor active in various cancers types including
renal cancers and endocrine tumors. The study analyzed the influence of the lean body …
renal cancers and endocrine tumors. The study analyzed the influence of the lean body …
Genomewide association study of atazanavir pharmacokinetics and hyperbilirubinemia in AIDS Clinical Trials Group protocol A5202
DH Johnson, C Venuto, MD Ritchie… - Pharmacogenetics …, 2014 - journals.lww.com
Background Atazanavir-associated hyperbilirubinemia can cause premature discontinuation
of atazanavir and avoidance of its initial prescription. We used genomewide genotyping and …
of atazanavir and avoidance of its initial prescription. We used genomewide genotyping and …
Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability
LC Mbatchi, JP Brouillet, A Evrard - Pharmacogenomics, 2018 - Taylor & Francis
NR1I2 (PXR) and NR1I3 (CAR) are nuclear receptors that are classified as xenoreceptors.
Upon activation by various xenobiotics, including marketed drugs, they regulate the …
Upon activation by various xenobiotics, including marketed drugs, they regulate the …
Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio)
ACD Bainy, A Kubota, JV Goldstone, R Lille-Langøy… - Aquatic toxicology, 2013 - Elsevier
The pregnane X receptor (PXR)(nuclear receptor NR1I2) is a ligand activated transcription
factor, mediating responses to diverse xenobiotic and endogenous chemicals. The …
factor, mediating responses to diverse xenobiotic and endogenous chemicals. The …