Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
In mammals, the insulin receptor (IR) gene has acquired an additional exon, exon 11. This
exon may be skipped in a developmental and tissue-specific manner. The IR, therefore …
exon may be skipped in a developmental and tissue-specific manner. The IR, therefore …
Cell cycle checkpoint signaling:: Cell cycle arrest versus apoptosis
JA Pietenpol, ZA Stewart - toxicology, 2002 - Elsevier
Although toxicants may initiate cell damage or stress, the cellular proteins that are involved
in control of cell cycle and apoptosis are the final arbiters of cell fate. The biochemical …
in control of cell cycle and apoptosis are the final arbiters of cell fate. The biochemical …
Substrate specificities and identification of putative substrates of ATM kinase family members
Ataxia telangiectasia mutated (ATM) phosphorylates p53 protein in response to ionizing
radiation, but the complex phenotype of AT cells suggests that it must have other cellular …
radiation, but the complex phenotype of AT cells suggests that it must have other cellular …
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
Eukaryotic cells activate an evolutionarily conserved set of proteins that rapidly induce cell
cycle arrest to prevent replication or segregation of damaged DNA before repair is …
cycle arrest to prevent replication or segregation of damaged DNA before repair is …
A plausible model for the digital response of p53 to DNA damage
Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is
“digital” in that it is the number of oscillations rather than the amplitude of p53 that shows …
“digital” in that it is the number of oscillations rather than the amplitude of p53 that shows …
Interaction of c-Abl and p73α and their collaboration to induce apoptosis
Abstract c-Abl, a non-receptor tyrosine kinase, is activated by agents that damage DNA. This
activation results in either arrest of the cell cycle in phase G1 or apoptotic cell death, both of …
activation results in either arrest of the cell cycle in phase G1 or apoptotic cell death, both of …
Hypoxia links ATR and p53 through replication arrest
EM Hammond, NC Denko, MJ Dorie… - … and cellular biology, 2002 - Taylor & Francis
Previous studies have demonstrated that phosphorylation of human p53 on serine 15
contributes to protein stabilization after DNA damage and that this is mediated by the ATM …
contributes to protein stabilization after DNA damage and that this is mediated by the ATM …
[HTML][HTML] Gadd45 in stress signaling
DA Liebermann, B Hoffman - Journal of molecular signaling, 2008 - Springer
Gadd45 genes have been implicated in stress signaling in response to physiological or
environmental stressors, which results in cell cycle arrest, DNA repair, cell survival and …
environmental stressors, which results in cell cycle arrest, DNA repair, cell survival and …
Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells
T Sanli, A Rashid, C Liu, S Harding, RG Bristow… - International Journal of …, 2010 - Elsevier
PURPOSE: Adenosine monophosphate (AMP)–activated kinase (AMPK) is a molecular
energy sensor regulated by the tumor suppressor LKB1. Starvation and growth factors …
energy sensor regulated by the tumor suppressor LKB1. Starvation and growth factors …
Prediction of radiation sensitivity using a gene expression classifier
JF Torres-Roca, S Eschrich, H Zhao, G Bloom, J Sung… - Cancer research, 2005 - AACR
The development of a successful radiation sensitivity predictive assay has been a major
goal of radiation biology for several decades. We have developed a radiation classifier that …
goal of radiation biology for several decades. We have developed a radiation classifier that …