Gender differences in the pathogenesis and risk factors of hepatocellular carcinoma
Simple Summary Significant gender disparities have been highlighted in the incidence,
aggressiveness, and prognosis of HCC. A different epidemiological distribution of the risk …
aggressiveness, and prognosis of HCC. A different epidemiological distribution of the risk …
Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and HCC
Only a few preclinical findings are confirmed in the clinic, posing a critical issue for clinical
development. Therefore, identifying the best preclinical models can help dissect molecular …
development. Therefore, identifying the best preclinical models can help dissect molecular …
Exploiting gender-based biomarkers and drug targets: advancing personalized therapeutic strategies in hepatocellular carcinoma
L Su, H Luo, Y Yan, Z Yang, J Lu, D Xu, L Du… - Frontiers in …, 2024 - frontiersin.org
This review systematically examines gender differences in hepatocellular carcinoma (HCC),
identifying the influence of sex hormones, genetic variance, and environmental factors on …
identifying the influence of sex hormones, genetic variance, and environmental factors on …
Constitutively active androgen receptor in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the predominant type of liver cancer and a leading
cause of cancer-related death globally. It is also a sexually dimorphic disease with a male …
cause of cancer-related death globally. It is also a sexually dimorphic disease with a male …
Dual and opposing roles of the androgen receptor in VETC-dependent and invasion-dependent metastasis of hepatocellular carcinoma
HC Zhou, CX Liu, WD Pan, LR Shang, JL Zheng… - Journal of …, 2021 - Elsevier
Background & Aims Contradictory roles of the androgen receptor (AR) in hepatocellular
carcinoma (HCC) metastasis have been reported. We have shown that VETC (vessels …
carcinoma (HCC) metastasis have been reported. We have shown that VETC (vessels …
RFX6 facilitates aerobic glycolysis‐mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1
Background Hepatocellular carcinoma (HCC) cells undergo reprogramming of glucose
metabolism to support uncontrolled proliferation, of which the intrinsic mechanism still merits …
metabolism to support uncontrolled proliferation, of which the intrinsic mechanism still merits …
LncRNA LINC00667 aggravates the progression of hepatocellular carcinoma by regulating androgen receptor expression as a miRNA-130a-3p sponge
Z Qin, X Liu, Z Li, G Wang, Z Feng, Y Liu, H Yang… - Cell death …, 2021 - nature.com
Emerging studies have found long noncoding RNAs, widely expressed in eukaryotes,
crucial regulators in the progression of human cancers, including hepatocellular carcinoma …
crucial regulators in the progression of human cancers, including hepatocellular carcinoma …
[HTML][HTML] Sex steroid axes in determining male predominance in hepatocellular carcinoma
L Zhang, JF Wu, QM Wu, XJ Zhang, SC Lin, WL Ran… - Cancer Letters, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. The
mechanisms for male propensity in HCC incidence, prognosis and treatment responses are …
mechanisms for male propensity in HCC incidence, prognosis and treatment responses are …
Toward improving androgen receptor-targeted therapies in male-dominant hepatocellular carcinoma
Highlights•AR is an oncogenic driver of hepatocellular carcinoma.•AR-targeted therapy is
limited by feedback activation of AKT-mTOR pathway.•Co-targeting of mTORC1 and AR may …
limited by feedback activation of AKT-mTOR pathway.•Co-targeting of mTORC1 and AR may …
Impact of alternative splicing variants on liver cancer biology
Simple Summary Among the top ten deadly solid tumors are the two most frequent liver
cancers, hepatocellular carcinoma, and intrahepatic cholangiocarcinoma, whose …
cancers, hepatocellular carcinoma, and intrahepatic cholangiocarcinoma, whose …