The core histone tails are critical in chromatin structure and signaling. Studies over the past
several decades have provided a wealth of information on the histone tails and their …

Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the
membraneless compartmentalization of the nucleus. Because chromatin compaction and …

In our cells, DNA is folded and packed with the help of many proteins into chromatin whose
basic unit is a nucleosome—DNA wrapped around octamer of histone proteins. The chain of …

Little is known about the roles of histone tails in modulating nucleosomal DNA accessibility
and its recognition by other macromolecules. Here we generate extensive atomic level …

Gene regulation programs establish cellular identity and rely on dynamic changes in the
structural packaging of genomic DNA. The DNA is packaged in chromatin, which is formed …

Molecular simulations of biological systems tend to be significantly more compute-intensive
than those in materials science and astrophysics, due to important contributions of long …

Abstract Protein arginine methyltransferase 1 (PRMT1) and the product of this enzyme
(histone H4 asymmetrically dimethylated at Arg 3; H4R3me2a) are important in the …

Epigenetic regulation, mainly involving DNA methylation, histone modification, and
noncoding RNAs, affects gene expression without modifying the primary DNA sequence and …

Linker histones are epigenetic regulators that bind to nucleosomes and alter chromatin
structures and dynamics. Biophysical studies have revealed two binding modes in the linker …

Fitting-free mechanistic models based on polymer simulations predict chromatin folding in
3D by focussing on the underlying biophysical mechanisms. This class of models has been …