BACKGROUND:: Fluorouracil (FU) is an antimetabolite with activity against numerous types
of neoplasms, including those of the breast, esophagus, larynx, and gastrointestinal and …

Because cancer is a leading cause of mortality in the United States, the number of
therapeutic modalities available for the treatment of neoplastic processes has increased …

Purpose This phase III study compared the safety and efficacy of the following three different
irinotecan-containing regimens in the first-line treatment of metastatic colorectal cancer …

Background The optimum use of cytotoxic drugs for advanced colorectal cancer has not
been defined. Our aim was to investigate whether combination treatment is better than …

Combination chemotherapy regimens including irinotecan and oxaliplatin markedly improve
response rate and prolong median survival over fluorouracil with leucovorin (FU/LV), and …

BACKGROUND The goal of the current study was to evaluate the efficacy and toxicity of
capecitabine in patients with nonresectable hepatobiliary carcinoma. METHODS The …

Irinotecan, a water-soluble, semisynthetic derivative of camptothecin, is a key component of
first-and second-line treatment regimens for metastatic colorectal cancer (CRC). In the first …

Purpose The AIO KRK-0104 randomized phase II trial investigated the efficacy and safety of
cetuximab combined with capecitabine and irinotecan (CAPIRI) or capecitabine and …

Purpose Decision making in advanced cancer is increasingly complex. We developed a
decision aid (DA) for patients with advanced colorectal cancer who are considering first-line …

About 50% of patients with colorectal cancer (CCR) are destined to develop hepatic
metastases during the course of the disease. Surgery is currently the only potentially …