[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
The growing landscape of lysine acetylation links metabolism and cell signalling
Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
Lysine acetylation goes global: from epigenetics to metabolism and therapeutics
Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …
[HTML][HTML] Protein lysine acetylation by p300/CBP
Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …
Protein ensembles: how does nature harness thermodynamic fluctuations for life? The diverse functional roles of conformational ensembles in the cell
All soluble proteins populate conformational ensembles that together constitute the native
state. Their fluctuations in water are intrinsic thermodynamic phenomena, and the …
state. Their fluctuations in water are intrinsic thermodynamic phenomena, and the …
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
JB Baell, DJ Leaver, SJ Hermans, GL Kelly… - Nature, 2018 - nature.com
Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin
organization and function. Among the genes coding for the MYST family of KATs (KAT5 …
organization and function. Among the genes coding for the MYST family of KATs (KAT5 …
[HTML][HTML] Histone modifications and their role in epigenetics of atopy and allergic diseases
B Alaskhar Alhamwe, R Khalaila, J Wolf… - Allergy, Asthma & …, 2018 - Springer
This review covers basic aspects of histone modification and the role of posttranslational
histone modifications in the development of allergic diseases, including the immune …
histone modifications in the development of allergic diseases, including the immune …
[HTML][HTML] Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy
S Migliozzi, YT Oh, M Hasanain, L Garofano… - Nature cancer, 2023 - nature.com
Despite producing a panoply of potential cancer-specific targets, the proteogenomic
characterization of human tumors has yet to demonstrate value for precision cancer …
characterization of human tumors has yet to demonstrate value for precision cancer …
Writers and readers of histone acetylation: structure, mechanism, and inhibition
R Marmorstein, MM Zhou - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Histone acetylation marks are written by histone acetyltransferases (HATs) and read by
bromodomains (BrDs), and less commonly by other protein modules. These proteins …
bromodomains (BrDs), and less commonly by other protein modules. These proteins …
Beyond histone acetylation—writing and erasing histone acylations
Highlights•Non-acetyl histone acylations are catalyzed by classical acetylation
modifiers.•Active site engagement of the acyl group determines acyl type-specific …
modifiers.•Active site engagement of the acyl group determines acyl type-specific …