Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Secondary metabolites are compounds not essential for an organism's development, but
provide significant ecological and physiological benefits. These compounds have …

Biosynthetic gene clusters (BGCs) are groups of clustered genes found in bacteria, fungi,
and some plants and animals that are crucial for synthesizing secondary metabolites. In …

Many clinically used drugs are derived from or inspired by bacterial natural products that
often are produced through nonribosomal peptide synthetases (NRPSs), megasynthetases …

The human microbiome emerges as a promising reservoir for diagnostic markers and
therapeutics. Since host-associated microbiomes at various body sites differ and diseases …

How to resolve the metabolic dark matter of microorganisms has long been a challenging
problem in discovering active molecules. Diverse omics tools have been developed to guide …

Bacteriocins are highly diverse, abundant, and heterogeneous antimicrobial peptides that
are ribosomally synthesized by bacteria and archaea. Since their discovery about a century …

The human lung microbiome remains largely underexplored, despite its potential
implications in the pharmacokinetics of inhaled drugs and its involvement in lung diseases …

Human health is greatly influenced by the gut microbiota and microbiota imbalance can lead
to the development of diseases. It is widely acknowledged that the interaction of bacteria …