The shared role of cholesterol in neuronal and peripheral inflammation
Neurodegeneration and its loss of cognitive function is associated with inflammation and an
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …
Cholesterol regulation of membrane proteins revealed by two-color super-resolution imaging
Cholesterol and phosphatidyl inositol 4, 5-bisphosphate (PIP2) are hydrophobic molecules
that regulate protein function in the plasma membrane of all cells. In this review, we discuss …
that regulate protein function in the plasma membrane of all cells. In this review, we discuss …
[HTML][HTML] Metabolic reprogramming of astrocytes in pathological conditions: implications for neurodegenerative diseases
C Calì, I Cantando, MF Veloz Castillo… - International journal of …, 2024 - mdpi.com
Astrocytes play a pivotal role in maintaining brain energy homeostasis, supporting neuronal
function through glycolysis and lipid metabolism. This review explores the metabolic …
function through glycolysis and lipid metabolism. This review explores the metabolic …
[HTML][HTML] Super-resolution imaging of potassium channels with genetically encoded EGFP
IM Call, JL Bois, SB Hansen - BioRxiv, 2023 - ncbi.nlm.nih.gov
The plasma membrane is a well-organized structure of lipids and proteins, segmented into
lipid compartments under 200 nm in size. This specific spatial patterning is crucial for the …
lipid compartments under 200 nm in size. This specific spatial patterning is crucial for the …
A multifactorial lens on risk factors promoting the progression of Alzheimer's disease
J Parker, JM Moris, LC Goodman, VK Paidisetty… - Brain Research, 2024 - Elsevier
The prevalence of Alzheimer's disease (AD) among adults has continued to increase over
the last two decades, which has sparked a significant increase in research that focuses on …
the last two decades, which has sparked a significant increase in research that focuses on …
The role of high cholesterol in SARS-CoV-2 infectivity
Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute
respiratory syndrome coronavirus 2. The virus binds to angiotensinogen converting enzyme …
respiratory syndrome coronavirus 2. The virus binds to angiotensinogen converting enzyme …
[HTML][HTML] Comparative gene regulatory networks modulating APOE expression in microglia and astrocytes
Background: Single-cell technologies have unveiled various transcriptional states in
different brain cell types. Transcription factors (TFs) regulate the expression of related gene …
different brain cell types. Transcription factors (TFs) regulate the expression of related gene …